After years of research into sirtuin activators, our international team of scientists first demonstrated their protective power against cerebral ischaemia and then their relationship with age-related mechanisms. The result is Sirt500 Plus, a natural compound made up of activators of sirtuins, proteins which are essential to the immune system, cell rejuvenation and have antioxidant and anti-inflammatory properties.


  • 1991 – Research into sirtuins begins with Leonard Guarente of MIT. It is known that mammals have seven sirtuins (SIRT1-7), which occupy different subcellular compartments: in the nucleus, SIRT1, 2, 6 and 7; in the cytoplasm, SIRT1 and 2; and in the mitochondria, SIRT3, 4 and 5. These studies were subsequently taken up by David A. Sinclair at the Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Biomedical Research Center in Baltimore.
  • 2017Giovanni Ciallella invests in research with the intention of developing a unique compound capable of stimulating the production of sirtuins, enabling anyone to rejuvenate naturally. Sirt500 Plus (A5+) is born.
  • 2020 –SirtLife is born and Sirt500 Plus begins selling in limited quantities. The product was enthusiastically received both in Italy and abroad. In July of the same year, production of the new Sirt500 Plus compound began. By the end of the year, Sirt500 Plus had more than 10,000 customers.
  • 2021 – The first review of the Sirt500 Plus (A5+) compound is now online. SirtLife is expanding in Italy, Switzerland (TISinc exclusivist) and the United States.

Mission & Vision

With a clear and ambitious aim, SIRTLIFE creates natural products designed and dedicated to extending healthy lifespans and the well-being of the body in all age groups.

The work of SirtLife is to combat ageing with high-end products. SirtLife’s basic aim is to offer a catalogue of targeted products dedicated to sirtuin activation and cell rejuvenation. Using top-quality raw materials processed using solvent-free procedures, we create natural and exclusive products that slow down the ageing process and help the body to solve physiological problems. The very first step in the journey to discover eternal youth.


All our products have certificates of reliability and quality. Thanks to many years of study and research, today Sirt500 Plus is a top quality natural sirtuin activator food supplement with proven reverse-aging and preventive properties, authorised by the Italian Ministry of Health for sale throughout Europe. A natural and exclusive product, created to prolong biological youth.


With the aim of achieving ever new goals and ambitions, SirtLife relies on the collaboration of partners with proven professional experience and scientific advice from some of the most prestigious universities in Italy and abroad. The guarantee and efficacy of our products are fundamental aspects. For this reason, our company is committed to proving their medical and scientific validity every day.

Press reports Sirt500 Plus.