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ELLAGIC ACID AND NERVOSOUS SYSTEM : protective effects of polyphenols

Ellagic acid and nervous system

With respect to the ineffectiveness of single-target drugs for the treatment of numerous neurodegenerative disorders, much attention has been paid to natural products with multidrug properties and negligible adverse effects. Ellagic acid is known as an important natural phenolic antioxidant, which is widely found in several fruits and vegetables. Recent studies have shown that ellagic acid can invoke a spectrum of cellular signaling pathways to attenuate or slow the development of neurodegenerative disorders.

Indeed, multiple lines of evidence suggest that disease-related neurodegeneration appears to be a multifactorial process involving several cytotoxic pathways that converge in cell death. Neuropathological evidence indicates that in neuroinflammation, excitotoxicity, redox-active metals, ellagic acid intervenes with potent neuroprotective effects through its free radical scavenging properties, iron chelation, activation of several cellular signaling pathways, and attenuation of mitochondrial dysfunction.

ellagic acid and nervous system

Ellagic acid and nervous system, scientific studies

In this study, the neuroprotective effects of ellagic acid were critically summarized and analyzed against the available literature with particular attention to its molecular mechanisms of action. In addition, the biosynthesis, sources, bioavailability, and metabolism of this natural compound are discussed to provide as accurately as possible the information necessary to evaluate the overall protective effects of this compound on the central nervous system.

Ellagic acid and nervous system a healthy eating strategy to protect oneself while maintaining well-being and longevity without chronic and autoimmune diseases by mimicking calorie restriction with natural polyphenol-based foods and supplements.

Editorial Staff SIRT500 – The Fountain of Youth

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