€ 0.00

No products in the cart.

Free 24-hour shipping in Italy and Switzerland for orders over 70€ /Chf - Secure payment method with Credit/Debit Card (PayPal)

€ 0.00

No products in the cart.

HONOKIOL ANTI-CANCER: anti-angiogenic, anti-inflammatory and anti-cancer properties OF POLYPHENOLS

Honokiol anti-cancer

Honokiol is a small polyphenolic molecule isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it shares some biological properties. Recently, honokiol was found to have antiangiogenic, anti-inflammatory, and anticancer properties in preclinical models, without appreciable toxicity. These findings have increased interest in bringing honokiol to the clinical stage as a novel chemotherapeutic agent.

In addition, recent studies have attempted to find the mechanism(s) of action of honokiol, for two main reasons. First, knowledge of the mechanism(s) of action may aid in the development of new synthetic analogs. Second, the systemic actions of honokiol may lead to rational combinations with conventional chemotherapy or radiation for improved response to systemic cancers. In this study, the results of the two main mechanisms of action of honokiol are described.

honokiol anti-cancer

Honokiol anti-cancer, scientific studies

First, it blocks signaling in tumors with defective function of p53 and activated ras by directly blocking phospholipase D activation by activated ras. Second, honokiol induces cyclophilin D, thereby enhancing the mitochondrial permeability transition pore, and causing death in cells with wild-type p53. Knowledge of the dual activities of this polyphenol may aid in the development of derivatives thereof and the design of clinical trials that will maximize the potential benefit of this valuable polyphenol in the patient setting.

Honokiol anti-cancer a healthy eating strategy to maintain well-being and longevity without chronic and autoimmune diseases by mimicking calorie restriction with natural polyphenol-based foods and supplements.

Editorial Staff SIRT500 – The Fountain of Youth

Lugano
scattered clouds
24.7 ° C
26.3 °
21.6 °
64 %
2.6kmh
40 %
Sun
25 °
Mon
23 °
Tue
25 °
Wed
22 °
Thu
24 °

LAST ARTICLES

SEMAGLUTIDE AND SLIMMING: losing weight quickly as a ‘side effect’

Semaglutide and slimming Conceived, researched and already used as a drug against diabetes, Semaglutide is literally flying off the shelves halfway around the world because...

Ashwagandha plant youth tonic, health and healthy longevity

Ashwagandha plant, what is it? The Ashwaganda plant is a member of the solanaceae and is commonly known as Indian ginseng or by its scientific...

SPEEDING UP METABOLISM: the solution to get through the swimming costume test

Speeding up metabolism The summer season is just around the corner and inevitably the swimming costume test confronts us with the many extra inches of...

SIRTLIFE PRODUCTS