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POLYDATIN AND CARDIOMYOPATHY: cardio-protective effects of polyphenols

Polydatin and cardiomyopathy

Diabetic cardiomyopathy is the main cause of increased morbidity in diabetic patients, no effective treatment is available to date. Polydatin, a resveratrol glycoside isolated from Polygonum cuspidatum, demonstrates antioxidant and cardioprotective activities. However, the therapeutic effects of polydatin on diabetic cardiomyopathy and possible mechanisms remain unclear. This study aimed to investigate the cardioprotective effects and underlying mechanisms of polydatin on hyperglycaemia-induced myocardial damage.

In diabetic rats, polydatin administration significantly improved myocardial dysfunction and attenuated histological abnormalities, as evidenced by increases in left ventricular shortening fraction and ejection fraction, as well as reduced cardiac hypertrophy and interstitial fibrosis. In cultured H9c2 cells, polydatin pretreatment dose-dependently inhibited glucose-induced cardiomyocyte damage.

polydatin and cardiomyopathy

Polydatin and cardiomyopathy, scientific studies

The results of this research show that the cardioprotective effect of polydatin against hyperglycaemia-induced myocardial damage is mediated by inhibition of NADPH oxidase and NF-κB activity. The results may provide new insight into the mechanisms of polydatin to be a potential treatment for diabetic cardiomyopathy.

Polydatin and cardiomyopathy a healthy eating strategy to protect oneself while maintaining well-being and longevity without chronic and autoimmune diseases by mimicking calorie restriction with natural polyphenol-based foods and supplements.

Editorial Staff SIRT500 – The Fountain of Youth

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