€ 0.00

No products in the cart.

Free 24-hour shipping in Italy and Switzerland for orders over 80€ /Chf - Secure payment method with PayPal technology

€ 0.00

No products in the cart.

LUNG CANCER: Polydatin inhibits cell growth by inducing apoptosis

Lung Cancer

Polydatin (PD), a small natural compound from Polygonum cuspidatum, has a number of biological functions. However, the antitumor activity of polytadin has been little studied. In the present study, the thiazolyl blue tetrazolium bromide assay was used to evaluate the inhibitory effect of polydatin on lung cancer cell growth.

Cell cycle distribution and apoptosis were studied by flow cytometry. In addition, the expression of several apoptosis- and cell cycle-associated proteins were analyzed by western blot analysis. The results showed that polydatin significantly inhibited the proliferation of A549 and NCI-H1975 cell lines and caused dose-dependent apoptosis.

Cell cycle analysis revealed that polydatin induces cell cycle arrest in S phase. Western blot analysis showed that the expression of Bcl-2 decreased while that of Bax increased, and the expression of cyclin D1 was also suppressed. The results suggest that polytadin has potential therapeutic applications in the treatment of lung cancer.

Editorial Staff La Fonte della Giovinezza

clear sky
8.4 ° C
11.2 °
5.6 °
67 %
0 %
8 °
8 °
6 °
9 °
6 °


SIRTUINE: exercise, fitness and reactivating longevity genes.

Physical activity and ageing The importance and significance of movement during the ageing phase for the activity of sirtuins has long been studied by scientists...

HAIR: strong, beautiful and healthy with the right diet.

Ideal substances There are many factors that can cause problems for our hair on a daily basis: shampoos, conditioners, sprays, hairsprays, gels, dyes and treatments....

SKIN: effectively combating skin ageing by reactivating sirtuins.

Genetic information There are several genes that have a huge impact on the skin. The research laboratories of the most famous cream brands first focused...