The decline in bone mass and strength as well as the musculoskeletal problems associated with ageing pose a major challenge to affected individuals and to the healthcare system globally. Sirtuins 1-7 (SIRT1-SIRT7) are a family of nicotinamide adenine dinucleotide-dependent deacetylases with remarkable capabilities to promote longevity and counteract age-related diseases.
Knockout and transgenic models of sirtuins have provided new insights into the function and signalling of these proteins in bone homeostasis. Several studies have shown that sirtuins play a critical role in normal skeletal development and homeostasis through their direct action on bone cells and that their dysregulation could contribute to several bone diseases. Preclinical studies have also shown that mice treated with sirtuin agonists show protection against age-, postmenopausal– and immobility-induced osteoporosis.
The results of this and several other studies suggest that sirtuins could be potential targets for modulating imbalance in bone remodelling and treating osteoporosis and other bone disorders. The aim of this research was to provide a comprehensive and up-to-date review of the current knowledge on the biology of sirtuins, focusing in particular on their roles in bone homeostasis and osteoporosis, and on potential pharmacological interventions targeting sirtuins for the treatment of osteoporosis.
Editorial Staff La Fonte della Giovinezza